Bariatric Surgery Cuts Microvascular Complications of Pre-diabetes

Bariatric surgery reduces the risk for microvascular complications, and, interestingly, this happens to an even greater degree among people with pre-diabetes than in those with diabetes, new results indicate.

The findings come from a post hoc analysis. 4032 of the original 4047 participants from the Swedish Obese Subjects (SOS) study.

After 15 years of follow-up, bariatric surgery was associated with reduced incidence of microvascular complications in those with diabetes, pre-diabetes, and normal glycemia prior to surgery. However, the largest risk reduction occurred among the prediabetes group.

“I think the most important finding is that prediabetes is a condition that should be treated more aggressively. This is to prevent microvascular complications and that bariatric surgery is an effective treatment.” lead author Lena MS Carlsson, MD, PhD, professor of clinical metabolic research at Sahlgrenska Academy, University of Gothenburg, Sweden, told Medscape Medical News.

She added, “Our conclusion is not that metabolic surgery should be used more widely. However, among obese patients who are considered for bariatric surgery, we think that those with prediabetes should be prioritized because they are at high risk for diabetes and complications, and this can be prevented if they are operated [on].”

Dr Carlsson and colleagues’ findings were published online recently in Lancet Diabetes & Endocrinology.

Indeed, in an accompanying editorial, George K Dimitriadis, of the University of Warwick Medical School, Coventry, United Kingdom, and colleagues point out, “Accumulating evidence suggests that pre-diabetes is not simply a state of abnormal glucose concentration but a prediagnosis of diabetes in which pathophysiological processes constituting microvascular and macrovascular complications might already be present.”


Read more about it on Med Scape here: